Ngwa ụlọ ọgwụ na nyocha nke PRP na ọrịa ikpere nkịtị

Ngwa ụlọ ọgwụ na nyocha nke PRP na ọrịa nkịtị nke nkwonkwo ikpere

Plasma bara ụba (PRP) bụ plasma mejupụtara nke kachasị nke platelet na sel ọbara ọcha enwetara site na centrifugation nke ọbara mpụta autologous.A na-echekwa ọnụ ọgụgụ buru ibu nke ihe na-eto eto na cytokines n'ime granules α nke platelet.Mgbe platelet na-arụ ọrụ, granules α ha na-ahapụ ọtụtụ ihe na-eto eto.Nnyocha e mere egosiwo na ihe ndị na-eto eto cell nwere ike ịkwalite ọdịiche nke cell, mmụba, matrix extracellular na collagen synthesis, si otú ahụ na-akwalite mmeghari na nrụzi nke cartilage articular na ligament.ọzọanụ ahụ.N'otu oge ahụ, ọ pụkwara imeziwanye nzaghachi mkpali nke saịtị ọnya ahụ ma belata mgbaàmà ahụike nke ndị ọrịa.Na mgbakwunye na ihe ndị na-eto eto cell, PRP nwekwara ọnụ ọgụgụ buru ibu nke mkpụrụ ndụ ọbara ọcha.Mkpụrụ ndụ ọbara ọcha ndị a na platelet nwere ike ịhapụ ụdị peptides antimicrobial dị iche iche iji jikọta nje ndị na-efe efe, gbochie ma gbuo nje, ma rụọ ọrụ antibacterial.

A na-eji PRP eme ihe n'ọtụtụ ebe na ngalaba orthopedics n'ihi usoro nrụpụta ya dị mfe, iji dị mma na ọnụ ala dị ala, karịsịa na ọgwụgwọ ọrịa ikpere n'afọ ndị na-adịbeghị anya.Isiokwu a ga-atụle ngwa ụlọ ọgwụ na nyocha nke plasma bara ụba nke platelet na ikpere osteoarthritis (KOA), mmerụ ahụ meniscus, mmerụ ahụ ligament cruciate, synovitis ikpere na ọrịa ikpere ndị ọzọ.

Teknụzụ ngwa PRP

PRP na-adịghị arụ ọrụ na ntọhapụ PRP na-arụ ọrụ bụ mmiri mmiri ma nwee ike ịgbanye ya, na PRP na-adịghị arụ ọrụ nwere ike ịchịkwa ya site na ijikwa calcium chloride ma ọ bụ thrombin iji chịkwaa oge agglutination ka e wee nwee ike ịmepụta gel ahụ mgbe ọ rutere ebe a na-achọsi ike, ka e wee nwee ike ịmepụta ya. nweta nzube nke nọgidere ntọhapụ nke uto ihe.

PRP ọgwụgwọ nke KOA

KOA bụ ọrịa ikpere na-emebi emebi nke ejiri na-aga n'ihu na-ebibi cartilage articular.Ọtụtụ n'ime ndị ọrịa ahụ bụ ndị agadi na ndị agadi.Ihe ngosi ụlọ ọgwụ nke KOA bụ mgbu ikpere, ọzịza, na njedebe ọrụ.Enweghị ahaghị nhata n'etiti njikọ na mwepu nke matrix articular cartilage bụ ihe ndabere nke ihe omume KOA.Ya mere, ịkwalite nrụzi cartilage na ịhazi nguzozi nke matrix cartilage bụ isi ihe maka ọgwụgwọ ya.

Ka ọ dị ugbu a, ọtụtụ ndị ọrịa KOA dị mma maka ọgwụgwọ mgbanwe.Ngwunye nkwonkwo ikpere nke hyaluronic acid, glucocorticoids na ọgwụ ndị ọzọ na ọgwụ mgbochi mkpali na-abụghị nke steroid na-ejikarị ọgwụgwọ mgbanwe.Site na nyocha miri emi nke PRP site n'aka ndị ọkà mmụta ụlọ na ndị mba ọzọ, ọgwụgwọ KOA na PRP aghọwo ihe na-arịwanye elu n'afọ ndị na-adịbeghị anya.

Usoro nke ime ihe:

1. Kwalite mmụba nke chondrocytes:

Site na ịlele mmetụta nke PRP na viability nke oke bekee chondrocytes, Wu J et al.chọpụtara na PRP kwalitere mmụba nke chondrocytes, ma kwuo na PRP nwere ike ichebe IL-1β-activated chondrocytes site na igbochi ntụgharị Wnt / β-catenin.

2. Mgbochi nke chondrocyte mkpali mmeghachi omume na degeneration:

Mgbe a na-arụ ọrụ, PRP na-ewepụta ọnụ ọgụgụ buru ibu nke ihe mgbochi mkpali, dị ka IL-1RA, TNF-Rⅰ, ⅱ, wdg Il-1ra nwere ike igbochi ọrụ IL-1 site na igbochi IL-1 receptor, na TNF-Rⅰ na ⅱ nwere ike igbochi ụzọ mgbaàmà metụtara TNF-a.

Ọmụmụ ihe dị irè:

Ihe ngosi bụ isi bụ nkwụsị nke mgbu na mmelite nke ọrụ ikpere.

Lin KY et al.tụnyere intra-articular injections nke LP-PRP na hyaluronic acid na nkịtị saline, wee chọpụta na ọgwụgwọ ọgwụgwọ nke abụọ mbụ dị iche iche dị mma karịa nke nkịtị saline otu na obere oge, nke kwadoro mmetụta ahụike nke LP-PRP. na hyaluronic acid, na nleba anya ogologo oge (mgbe 1 afọ gasịrị) gosiri na mmetụta LP-PRP dị mma.Ụfọdụ ọmụmụ ejikọtawo PRP na hyaluronic acid, ma chọpụta na nchikota nke PRP na hyaluronic acid nwere ike ọ bụghị nanị na-ebelata ihe mgbu na imeziwanye ọrụ, ma na-akwadokwa ịmaliteghachi cartilage articular site na X-ray.

Agbanyeghị, Filardo G et al.kwenyere na otu PRP na sodium hyaluronate otu dị irè n'ịkwalite ọrụ ikpere na mgbaàmà site na nchọpụta a na-achịkwaghị achịkwa, ma ọ dịghị ihe dị iche iche a chọtara.Achọpụtara na ụzọ nchịkwa PRP nwere mmetụta ụfọdụ na mmetụta ọgwụgwọ nke KOA.Du W et al.emeso KOA na intravarticular injection PRP na extraarticular injection, na hụrụ VAS na Lysholm akara tupu ọgwụ na 1 na 6 ọnwa mgbe ọgwụ.Ha chọpụtara na ụzọ ịgba ọgwụ abụọ ahụ nwere ike imeziwanye akara VAS na Lysholm n'oge dị mkpirikpi, mana mmetụta nke intra-articular injection group dị mma karịa otu injection extraarticular ka ọnwa isii gachara.Taniguchi Y et al.kewara ọmụmụ banyere ọgwụgwọ KOA dị oke ma dị njọ n'ime injection intraluminal jikọtara ya na intraluminal injection nke PRP otu, intraluminal injection nke PRP otu na intraluminal injection nke HA otu.Ọmụmụ ihe ahụ gosiri na nchikota nke intraluminal injection nke PRP na intraluminal injections nke PRP dị mma karịa intraluminal injections nke PRP ma ọ bụ HA maka ọ dịkarịa ala ọnwa 18 iji meziwanye akara VAS na WOMAC.

(A na-ebipụtaghachi ọdịnaya nke isiokwu a, ma anyị anaghị enye nkwa ọ bụla ma ọ bụ nkwenye doro anya maka izi ezi, ntụkwasị obi ma ọ bụ izu oke nke ọdịnaya dị n'ime edemede a, ọ bụghịkwa maka echiche nke isiokwu a, biko ghọta.)