Ngwa nke ọgwụgwọ PRP na ọgwụgwọ AGA

Platelet Ọgaranya Plasma (PRP)

PRP adọtala uche n'ihi na ọ nwere ihe dị iche iche na-eto eto, a na-ejikwa ya na ịwa ahụ maxillofacial, orthopedics, plastic surgery, ophthalmology na ubi ndị ọzọ.Na 2006, Uebel et al.mbụ nwara pretreat follicular nkeji ka a transplanted na PRP wee hụ na e jiri ya tụnyere ebe a na-achịkwa isi isi, ebe a na-atụgharị ntutu isi nke PRP na-adị ndụ 18.7 follicular units/cm2, ebe ndị na-achịkwa na-adị ndụ 16.4 follicular nkeji./ cm2, njupụta ahụ mụbara site na 15.1%.Ya mere, a na-eche na ihe ndị na-eto eto nke platelet na-ewepụta nwere ike ime na sel stem nke ntutu isi, na-akpali ọdịiche nke mkpụrụ ndụ stem ma kwalite nhazi nke arịa ọbara ọhụrụ.

Na 2011, Takikawa et al.etinyere saline nkịtị, PRP, heparin-protamine microparticles jikọtara ya na PRP (PRP & D / P MPs) na subcutaneous injection nke ndị ọrịa AGA iji melite njikwa.Nsonaazụ gosiri na mpaghara cross-section nke ntutu na PRP otu na PRP & D / P MPs abawanyela nke ukwuu, eriri collagen na fibroblasts na ntutu isi na-amụba n'okpuru microscope, na arịa ọbara gburugburu. ajị ajị amụbawanye.

PRP bara ụba na ihe uto sitere na platelet.Ndị na-edozi protein ndị a dị mkpa na-achịkwa ịkwaga cell, ntinye, mmụba, na ọdịiche dị iche iche, na-akwalite nchịkọta nke matrix extracellular, na ọtụtụ ihe na-eto eto na-akwalite uto ntutu isi: ihe ndị na-eto eto na PRP na-emekọ ihe na ntutu isi.Nchikota nke sel stem nke mgbịrịgba na-ebute mmụba nke ntutu isi, na-emepụta nkeji follicular, ma na-akwalite ntutu isi.Na mgbakwunye, ọ nwere ike mee ka mmeghachi omume cascade dị ala ma kwalite angiogenesis.

Ọnọdụ PRP dị ugbu a na ọgwụgwọ AGA

A ka enwebeghị nkwenye na usoro nkwadebe na ihe na-eme ka platelet dịkwuo elu nke PRP;usoro ọgwụgwọ dịgasị iche iche na ọnụọgụ ọgwụgwọ, oge etiti oge, oge nkwụghachi azụ, usoro injection, na ma a na-eji ọgwụ jikọtara ọnụ.

Mapar et al.gụnyere ndị ọrịa nwoke 17 nwere ọkwa IV ruo VI (Hamilton-Norwood staging method), na nsonaazụ ya egosighi ihe dị iche n'etiti PRP na placebo injections, mana ọmụmụ ihe ahụ mere naanị 2 injections, na ọnụ ọgụgụ ọgwụgwọ dị ntakịrị.Nsonaazụ ghere oghe maka ajụjụ.;

Gkini et al chọpụtara na ndị ọrịa nwere ọkwa dị ala gosipụtara nzaghachi dị elu na ọgwụgwọ PRP;Qu et al kwadoro echiche a, nke gụnyere ụmụ nwoke 51 na ndị inyom 42 nwere ọkwa II-V na ụmụ nwoke na m na ụmụ nwanyị ~ Stage III (nhazi bụ Hamilton-Norwood na Ludwig staging method), nsonaazụ na-egosi na ọgwụgwọ PRP nwere. ọnụ ọgụgụ dị ịrịba ama dị iche iche na ndị ọrịa nwere ọkwa dị iche iche nke ndị ikom na ndị inyom, ma ịdị irè nke ọkwa dị ala na ọkwa dị elu ka mma, ya mere, ndị nchọpụta na-akwado II , Stage III ndị ọrịa nwoke na ogbo m ndị inyom na-arịa ọrịa PRP.

Ihe na-eme ka ọ dịkwuo mma

Ọdịiche dị n'ụdị nkwadebe nke PRP na ọmụmụ ihe ọ bụla mere ka ụdị nkwalite PRP dị iche iche dị na ọmụmụ ọ bụla, ọtụtụ n'ime ha gbadoro ụkwụ n'etiti oge 2 na 6.Platelet degenranulation na-ewepụta ọnụ ọgụgụ dị ukwuu nke ihe na-eto eto, na-achịkwa ịkwaga cell, ntinye, mmụba na ọdịiche, na-akpali mgbasa nke mkpụrụ ndụ follicle ntutu isi, vaskụla anụ ahụ, ma na-akwalite nchịkọta nke matrix extracellular.N'otu oge ahụ, a na-ewere usoro ọgwụgwọ microneedling na obere ike laser dị ka ihe na-emepụta mmebi anụ ahụ na-achịkwa ma na-akpali usoro mmebi platelet eke, nke na-ekpebi àgwà ngwaahịa nke PRP dabere na ọrụ ndụ ya.Ya mere, ọ dị mkpa iji nyochaa ntinye uche nke PRP dị irè.Ụfọdụ ọmụmụ kwenyere na PRP nwere ngwungwu ịba ụba nke ugboro 1-3 dị irè karịa ogige nkwalite dị elu, mana Ayatollahi et al.ejiri PRP mee ihe na ntinye nkwalite nke 1.6 ugboro maka ọgwụgwọ, na nsonaazụ gosiri na ọgwụgwọ nke ndị ọrịa AGA adịghị arụ ọrụ, ma kwenye na PRP Ntụle dị irè kwesịrị ịbụ oge 4 ~ 7.

Ọnụọgụ nke ọgwụgwọ, oge etiti oge na oge nkwụghachi azụ

Ọmụmụ nke Mapar et al.na Puig et al.ha abụọ nwetara nsonaazụ ọjọọ.Ọnụ ọgụgụ nke ọgwụgwọ PRP na usoro ọmụmụ abụọ a bụ 1 na 2 ugboro, n'otu n'otu, nke dị ala karịa ọmụmụ ndị ọzọ (karịsịa 3-6 ugboro).Picard et al.chọpụtara na ịdị irè nke PRP ruru elu ya mgbe ọgwụgwọ 3 ruo 5 gasịrị, n'ihi ya, ha kwenyere na ihe karịrị ọgwụgwọ 3 nwere ike ịdị mkpa iji meziwanye mgbaàmà nke ntutu isi.

Nyocha Gupta na Carviel chọpụtara na ọtụtụ n'ime ọmụmụ ihe ndị dị ugbu a nwere oge ọgwụgwọ nke ọnwa 1, na n'ihi ọnụ ọgụgụ dị nta nke ọmụmụ ihe, a naghị atụnyere nsonaazụ ọgwụgwọ na injections PRP kwa ọnwa na ugboro ugboro ndị ọzọ, dị ka injections PRP kwa izu.

Nnyocha nke Hausauer na Jones [20] gosiri na isiokwu ndị na-anata injections kwa ọnwa nwere mmụba dị ukwuu na ọnụ ọgụgụ ntutu ma e jiri ya tụnyere ugboro nke injections kwa ọnwa 3 (P<0.001);Shiavone et al.[21] kwubiri na, a ghaghị ịmeghachi ọgwụgwọ 10 ruo 12 ọnwa mgbe njedebe nke usoro ọgwụgwọ gasịrị;Gentile et al.sochiri maka afọ 2, oge nleba anya kachasị ogologo n'etiti ọmụmụ ihe niile, wee chọpụta na ụfọdụ ndị ọrịa na-alaghachi na ọnwa 12 (ikpe 4/20), na ndị ọrịa 16, mgbaàmà na-apụta ìhè na ọnwa.

Na nlebanya Sclafani, achọpụtara na arụmọrụ nke ndị ọrịa belatara nke ukwuu ọnwa 4 ka ngwụcha usoro ọgwụgwọ ahụ gasịrị.Picard et al.zoro aka na nsonaazụ ya ma nye ndụmọdụ ọgwụgwọ kwekọrọ na ya: mgbe oge nhazi nke 3 ọgwụgwọ nke ọnwa 1 gasịrị, a ga-eme ọgwụgwọ ahụ ugboro atọ ọ bụla.Ọgwụgwọ kpụ ọkụ n'ọnụ kwa ọnwa.Agbanyeghị, Sclafani akọwaghị oke mmụba platelet nke nkwadebe eji na usoro ọgwụgwọ.N'ime ọmụmụ ihe a, a kwadebere 8-9 ml nke platelet-ọgaranya fibrin matrix nkwadebe site na 18 ml nke ọbara dị n'akụkụ (a na-agbakwunye PRP a na-amịpụta na tube CaCl2, na-etinye fibrin gluu n'ime gluu fibrin. injection tupu e guzobe) , anyị kwenyere na nrịba ụba nke platelet n'ime nkwadebe a nwere ike ọ gaghị ezu oke, na a chọkwuru ihe akaebe iji kwado ya.

Usoro ịgba ọgwụ

Ọtụtụ n'ime ụzọ ịgba ahụ bụ ịgba ọgwụ mgbochi intradermal na ntụtụ subcutaneous.Ndị nchọpụta ahụ tụlere mmetụta nke usoro nchịkwa na mmetụta ọgwụgwọ.Gupta na Carviel tụrụ aro ịgba ntụtụ subcutaneous.Ụfọdụ ndị nchọpụta na-eji injection intradermal.Intradermal injection nwere ike igbu oge ịbanye PRP n'ime ọbara, belata ọnụego metabolic, mee ka oge nke ime obodo dịkwuo ogologo, ma mee ka mkpali nke dermis dịkwuo elu iji kwalite uto ntutu.na omimi abụghị otu.Anyị na-akwado na a ga-eji usoro ịgba ọgwụ Nappage mee ihe nke ọma mgbe a na-eme injections intradermal ewepu mmetụta nke ọdịiche injection, anyị na-akwadokwa ka ndị ọrịa kpụọ ntutu isi ha mkpụmkpụ iji lelee ntụziaka nke ntutu isi, ma dozie akụkụ ntinye agịga nke ọma dịka ya siri dị. ntụzịaka na-eto eto ka ọnụ ọnụ agịga wee nwee ike iru gburugburu ntutu isi, si otú ahụ na-amụba mkpokọta PRP mpaghara na ntutu isi.Ndụmọdụ ndị a gbasara usoro ịgba ọgwụ bụ naanị maka ntụnye aka, ebe ọ nweghị ọmụmụ ihe na-atụnyere uru na ọghọm dị n'ụzọ dị iche iche ịgba ọgwụ.

Usoro ọgwụgwọ ngwakọta

Jha et al.eji PRP jikọtara ya na microneedling na 5% minoxidil ngwakọta ọgwụgwọ iji gosipụta ezigbo nrụpụta na ma ihe akaebe ebumnuche na nyocha onwe onye ọrịa.Anyị ka na-eche ihe ịma aka ihu na ịhazi usoro ọgwụgwọ maka PRP.Ọ bụ ezie na ọtụtụ ọmụmụ na-eji qualitative na quantitative ụzọ iji chọpụta mmelite mgbaàmà mgbe ọgwụgwọ gasịrị, dị ka ọnụ ọgụgụ ntutu isi, ọnụ ọgụgụ ntutu vellus, ntutu isi, njupụta, ọkpụrụkpụ, wdg, usoro nyocha dịgasị iche iche;na mgbakwunye, nkwadebe nke PRP Enweghị ọkọlọtọ edo edo na usoro, na-agbakwunye activator, oge centrifugation na ọsọ ọsọ, ntinye platelet, wdg;usoro ọgwụgwọ dịgasị iche iche na ọnụọgụ ọgwụgwọ, oge etiti oge, oge nkwụghachi azụ, usoro injection, na ma ọ ga-ejikọta ọgwụ;Nhọrọ nke ihe nlele na ọmụmụ ihe abụghị Stratification site na afọ, okike, na ogo nke alopecia na-eme ka nleba anya nke mmetụta ọgwụgwọ PRP.N'ọdịnihu, a ka na-achọkwu ihe ọmụmụ njide onwe onye ka ọ dị mkpa iji dokwuo anya usoro ọgwụgwọ dị iche iche, na nyocha ọzọ nke ọma nke ihe ndị dị ka afọ onye ọrịa, okike, na ogo nke ntutu isi nwere ike iji nwayọọ nwayọọ dịkwuo mma.

(A na-ebipụtaghachi ọdịnaya nke isiokwu a, ma anyị anaghị enye nkwa ọ bụla ma ọ bụ nkwenye doro anya maka izi ezi, ntụkwasị obi ma ọ bụ izu oke nke ọdịnaya dị n'ime edemede a, ọ bụghịkwa maka echiche nke isiokwu a, biko ghọta.)