PRP na-eme site na mbelata alfa granules sitere na platelet, nke nwere ọtụtụ ihe na-eto eto.Ihe nzuzo na-arụ ọrụ nke ihe ndị a na-eto eto na-amalite site na usoro nchịkọta ọbara ma malite n'ime nkeji 10 nke coagulation.A na-ezobe ihe karịrị 95% nke ihe ndị na-eto eto tupu ahazi n'ime otu awa.Ya mere, a ga-akwadorịrị PRP na steeti anticoagulant na a ga-eji ya mee ihe na grafts, flaps, ma ọ bụ ọnya n'ime nkeji 10 nke mmalite clot.Ọmụmụ ihe na-adịghị eji anticoagulated ọbara dum abụghị eziokwu PRP ọmụmụ na-eduhie eduhie.
Dị ka platelet na-arụ ọrụ site na usoro mkpụkọ, a na-ezobe ihe ndị na-eto eto site na cell site na akpụkpọ ahụ cell.N'ime usoro a, mkpụrụ irighiri alfa na-ejikọta membranes cell platelet, na ihe ndị na-eto eto protein na-emecha ọnọdụ bioactive site n'itinye ụdọ histone na carbohydrate na protein ndị a.Ya mere, platelet mebiri emebi ma ọ bụ mebie ya site na ọgwụgwọ PRP anaghị ezobe ihe na-eto eto bioactive ma nwee ike ibute nsonaazụ na-akụda mmụọ.Ihe na-eto eto zoro ezo na-ejikọta ozugbo na elu elu nke akpụkpọ ahụ nke mkpụrụ ndụ na aka, flap, ma ọ bụ ọnya site na ndị na-anabata transmembrane.
Nnyocha egosiwo na ndị okenye mmadụ mesenchymal stem cell, osteoblasts, fibroblasts, endothelial cell, na epidermal cell na-egosipụta ndị na-anabata akpụkpọ anụ cell maka ihe ndị na-eto eto na PRP.Ndị na-anabata transmembrane ndị a na-eme ka ndị na-emepụta ihe na-eme ka ndị na-edozi ahụ pụta ìhè na-eduga na nkwupụta (mkpọghe) nke usoro mkpụrụ ndụ cell nkịtị, dị ka mmụba cell, nhazi nke matrix, nhazi osteoid, collagen synthesis, wdg.
Ihe dị mkpa nke ihe ọmụma a bụ na ihe ndị na-eto eto PRP adịghị abanye na cell ma ọ bụ nucleus, ha abụghị mutagenic, ha na-eme ka mkpali nke ọgwụgwọ nkịtị dị ngwa ngwa.Ya mere, PRP enweghị ike ime ka ọkpụkpụ tumor.
Mgbe mmalite mmalite nke ihe uto metụtara PRP, platelet na-emepụta ma zoo ihe ndị ọzọ na-eto eto maka ụbọchị 7 fọdụrụ nke ndụ ha.Ozugbo platelet agwụla ma nwụọ, macrophages na-erute mpaghara ahụ site na arịa ọbara na-akpali akpali na-etolite n'ime iji rụọ ọrụ nke onye na-ahụ maka ọgwụgwọ ọnya site na izopụta ụfọdụ ihe na-eto eto yana ndị ọzọ.Ya mere, ọnụ ọgụgụ platelet dị na aka aka, ọnya, ma ọ bụ mkpụkọ ọbara nke etinyere na flap na-ekpebi ka ọnya ahụ na-adị ngwa ngwa.PRP na-agbakwunye na nọmba ahụ.
Kedu platelet ole ezuru?
Nnyocha egosiwo na mmụba na ọdịiche nke MSCS toro eto na-ejikọta kpọmkwem na ntinye uche nke platelet.Ha gosipụtara usoro nzaghachi dose, nke gosiri na nzaghachi cellular zuru oke na ntinye uche platelet malitere mgbe ugboro anọ ruo ise ruru ọnụọgụ platelet ntọala.Ọmụmụ ihe yiri nke ahụ gosiri na ịba ụba platelet na-abawanye ụba nke fibroblast na ụdị m mmepụta collagen, na ọtụtụ nzaghachi bụ PH-adabere na nzaghachi kachasị mma na-eme na ọkwa pH acid.
Ọmụmụ ihe ndị a ọ bụghị nanị na-egosi mkpa ngwaọrụ iji tinye uche na platelet zuru ezu, kamakwa kọwapụtara ihe nrụpụta ọkpụkpụ na-eme ka ọ dịkwuo mma na nkwalite anụ ahụ dị nro jikọtara ya na PRP.
Ebe ọ bụ na ọtụtụ ndị mmadụ nwere ọnụ ọgụgụ platelet ntọala nke 200,000 ± 75,000 kwa μl, ọnụ ọgụgụ PRP platelet nke 1 nde kwa μl a tụrụ na ọkọlọtọ 6-ml aliquots aghọwo akara ngosi maka "PRP ọgwụgwọ."N'ụzọ dị mkpa, ọmụmụ egosila na a na-enweta mkpokọta platelet a mgbe ọkwa ọgwụgwọ ruru, si otú a na-ewepụta ihe ndị na-eto eto.
(A na-ebipụtaghachi ọdịnaya nke isiokwu a, ma anyị anaghị enye nkwa ọ bụla ma ọ bụ nkwenye doro anya maka izi ezi, ntụkwasị obi ma ọ bụ izu oke nke ọdịnaya dị n'ime edemede a, ọ bụghịkwa maka echiche nke isiokwu a, biko ghọta.)
Oge nzipu: Sep-01-2022