Androgenic alopecia (AGA) bụ ụdị ntutu a na-ahụkarị nke sitere na ihe nketa na homonụ na-akpata, bụ nke a na-eji na-akpụ ntutu isi.N'ime ndị 60 afọ, 45% nke ndị ikom na 35% nke ụmụ nwanyị na-eche nsogbu nke AGA ihu.Usoro ọgwụgwọ AGA kwadoro FDA na-agụnye finasteride ọnụ na minoxidil topal.Ka ọ dị ugbu a, n'ihi enweghị ọgwụgwọ dị irè, PRP aghọwo ọgwụgwọ ọhụrụ na-ekwe nkwa ọzọ.Ọnụ ọgụgụ dị ukwuu nke ihe ndị na-eto eto na PRP nwere ike ịkwalite ntutu isi na platelet α Ụdị dị iche iche nke uto na-ezobe site na granules na-arụ ọrụ na sel steepụ na mpaghara ntutu isi na-akpali akpali ma na-eme ka e nwee arịa ọbara ọhụrụ.Ọ bụ ezie na ọtụtụ akụkọ akọpụtala nke a, ọ nweghị ụkpụrụ ọkọlọtọ maka nkwadebe PRP, ụzọ nchịkwa na nyocha nke nsonaazụ ụlọ ọgwụ.Isiokwu a na-achọ ịtụle ịdị irè nke PRP na ọgwụgwọ AGA ma chọpụta ọgwụgwọ dị iche iche dị.
Usoro ọrụ nke PRP:
A na-arụ ọrụ PRP mgbe etinyere ya n'isi iji hapụ ọnụ ọgụgụ buru ibu nke ihe na-eto eto ma kwalite uto ntutu.Ihe ndị a na-eto eto nwere ike ime ka fibroblasts rụọ ọrụ, na-akwalite njikọ nke collagen, melite secretion matrix extracellular ma na-ahazi okwu nke ihe uto endogenous.Ihe na-eto eto (PDGF, TGF- β, VEGF, EGF, IGF-1) nwere ike ịkwalite mgbasawanye cell na ọdịiche dị iche iche, mkpụrụ ndụ mkpụrụ ndụ chemotactic, mee ka ogologo ntutu isi na-eto eto, na-akwalite angiogenesis nke ntutu isi.Ihe ndị ọzọ (serotonin, histamine, dopamine, calcium na adenosine) nwere ike ime ka akpụkpọ ahụ dịkwuo mma ma mezie mbufụt.
Nkwadebe PRP:
Atụmatụ nkwadebe PRP niile na-agbaso iwu izugbe, a na-agbakwunye ọgwụ mgbochi ọbara (dị ka citrate) n'ọbara anakọtara iji zere coagulation na-atụghị anya ya na ịgbalite platelet.Centrifuge iji wepụ mkpụrụ ndụ ọbara uhie na itinye uche platelet.Na mgbakwunye, ọtụtụ atụmatụ na-ahọrọ ndị na-arụ ọrụ platelet exogenous (dị ka thrombin na calcium chloride) iji kwalite mwepụta ngwa ngwa nke ihe na-eto eto na platelet n'ụzọ dabere na dose.A pụkwara ịgbalite platelet na-adịghị arụ ọrụ site na collagen dermal ma ọ bụ autothrombin.N'ozuzu, a na-ezobe ihe na-eto eto na-arụ ọrụ nkeji 10 ka arụ ọrụ ya, na 95% nke ihe na-eto eto na-emepụta na-ewepụta n'ime 1 hour, na-adịgide adịgide maka otu izu.
Atụmatụ ọgwụgwọ na itinye uche:
A na-agbakarị PRP n'okpuru akpụkpọ anụ ma ọ bụ intradermally.Ugbu a, ewepụtabeghị oge ọgwụgwọ kacha mma na etiti oge.Ntinye uche nke PRP bụ ihe dị mkpa na-emetụta mmetụta ahụike.Edere isiokwu asaa gụnyere na ntinye kachasị mma nke PRP bụ oge 2 ~ 6, na itinye uche dị ukwuu ga-egbochi angiogenesis.A ka nwere esemokwu gbasara ma ọ nwere mkpụrụ ndụ ọbara ọcha.
Nsonaazụ nyocha dị ugbu a na-egosi nke ahụEnwere ike iji PRP mee ihe na ọgwụgwọ AGA.Asaa n'ime nyocha itoolu kọwara nsonaazụ dị mma.A tụlere ịdị irè nke PRP site n'ọtụtụ ụzọ: usoro nchọpụta PTG, nyocha ntutu isi, ọnụ ọgụgụ ntutu na njupụta ntutu, oge uto ruo oge ezumike, na nyocha afọ ojuju ndị ọrịa.Ụfọdụ ọmụmụ na-akọ naanị mmetụta mmelite nke ntinye ọnwa 3 mgbe ọgwụgwọ PRP gasịrị, mana enweghi nsonaazụ ntinye ọnwa 6.Ụfọdụ ọmụmụ ihe na-esote ogologo oge (ọnwa 6 ruo 12) kọrọ na mbelata nke njupụta ntutu isi, ma ọ ka dị elu karịa ọkwa ntọala.A kọrọ mmetụta ndị dị n'akụkụ naanị dị ka mgbu na-adịru nwa oge na mpaghara ịgba ọgwụ.Enweghị mmeghachi omume ọjọọ a kọrọ.
Ọgwụgwọ akwadoro:
Ebe ọ bụ na PRP anaghị egbochi ọkwa hormone metụtara AGA, a na-atụ aro ka a na-eji PRP mee ihe dị ka ọgwụgwọ adjuvant maka AGA.Ya mere, a ga-agba ndị ọrịa ume ka ha nọgide na-enwe ọgwụ ndị dị n'elu ma ọ bụ ọnụ (dị ka minoxidil, spironolactone na finasteride).Dabere na nyocha a na-atụgharị uche, a na-atụ aro ka ịkwadebe P-PRP (leukopenia) na ntinye uche 3-6 nke ọbara dum.Ojiji nke activators (calcium chloride ma ọ bụ calcium gluconate) tupu ọgwụgwọ na-enyere aka ịhapụ ihe ndị na-eto eto.A na-atụ aro na a ga-esi na akụkụ ahụ nwere ntutu na-adịghị ahụkebe, n'akụkụ ntutu isi na n'elu, a ga-ekewakwa ebe ịgba ahụ.A na-ekpebi dose injection site na mkpa ụlọ ọgwụ.A na-ahọrọ ugboro ntụtụ maka usoro ọgwụgwọ mbụ (otu ugboro n'ọnwa, ugboro atọ n'ozuzu, ọnwa atọ), na mgbe ahụ otu ugboro kwa ọnwa atọ, ugboro atọ na mkpokọta (ya bụ, otu ugboro na June, September na December n'otu n'otu).N'ezie, mgbe usoro ọgwụgwọ mbụ gasịrị, ọ dịkwa irè ịgbanwe oge etiti oge ka ọ bụrụ otu ugboro kwa ọnwa isii.N'ozuzu, ndị nwoke na nwanyị na-arịa ọrịa enwetawo nsonaazụ dị mma na ntutu isi, mmụba njupụta ntutu na ịdị mma nke ndụ mgbe ha gbasasịrị PRP iji na-emeso AGA (Foto 1 na Foto 2).
Mmechi:
Nyochaa nke ọtụtụ nchọpụta nchọpụta na-egosi na PRP na-ekwe nkwa na ọgwụgwọ AGA.N'otu oge ahụ, ọgwụgwọ PRP yiri ka ọ dị nchebe na obere mmetụta.Otú ọ dị, a ka na-enwekwaghị usoro nkwadebe PRP ahaziri ahazi, ntinye uche, atụmatụ ịgba ọgwụ, usoro onunu ogwu, wdg. Ya mere, ọ na-esiri ike iji nyochaa ịdị irè ụlọ ọgwụ nke PRP.Iji mụtakwuo mmetụta PRP na ntutu isi na AGA, a na-achọ nnukwu ihe nlele nke ule a na-achịkwa (rịba ama ugboro ugboro injection, ntinye PRP, ma nweta nleba anya ogologo oge).
(A na-ebipụtaghachi ọdịnaya nke isiokwu a, ma anyị anaghị enye nkwa ọ bụla ma ọ bụ nkwenye doro anya maka izi ezi, ntụkwasị obi ma ọ bụ izu oke nke ọdịnaya dị n'ime edemede a, ọ bụghịkwa maka echiche nke isiokwu a, biko ghọta.)
Oge nzipu: Dec-08-2022