Akụkọ ihe mere eme nke Platelet Rich Plasma (PRP)

Banyere Platelet Rich Plasma (PRP)

Platelet-rich plasma (PRP) nwere uru ọgwụgwọ yiri ya na sel stem ma ugbu a bụ otu n'ime ndị na-ahụ maka ọgwụgwọ na-ekwe nkwa ọgwụgwọ na-emegharị ahụ.A na-ejikarị ya eme ihe na ngalaba ahụike dị iche iche, gụnyere ịchọ mma akpụkpọ anụ, ọkpụkpụ ọkpụkpụ, ọgwụ egwuregwu na ịwa ahụ.

N'afọ 1842, a chọtara ihe ndị ọzọ na-abụghị mkpụrụ ndụ ọbara uhie na nke ọcha n'ọbara, nke tụrụ ndị ya na ha dịkọrọ ndụ anya.Julius Bizozero bụ onye mbụ kpọrọ aha nhazi platelet ọhụrụ "le piastrine del sangue" - platelet.Na 1882, ọ kọwara ọrụ platelet na coagulation in vitro na itinye aka na etiology nke thrombosis na vivo.Ọ chọpụtakwara na mgbidi arịa ọbara na-egbochi nnabata platelet.Wright nwere ọganihu ọzọ na mmepe nke usoro ọgwụgwọ na-emegharị ahụ site na nchọpụta ya nke macrokaryocytes, bụ ndị na-ebute platelet.Na mmalite 1940s, ndị dọkịta na-eji "mwepụta" embrayo na-agụnye ihe ndị na-eto eto na cytokines iji kwalite ọgwụgwọ ọnya.Ngwọta ọnya ngwa ngwa na nke ọma dị oke mkpa maka ịga nke ọma nke usoro ịwa ahụ.Ya mere, Eugen Cronkite et al.ewebata ngwakọta nke thrombin na fibrin n'ime akpụkpọ anụ.Site n'iji ihe ndị a dị n'elu, a na-eme ka njikọ siri ike ma kwụsie ike nke flap, nke na-arụ ọrụ dị mkpa n'ụdị ịwa ahụ.

Na mmalite narị afọ nke 20, ndị dọkịta ghọtara mkpa ọ dị ngwa iwebata mmịnye platelet iji gwọọ thrombocytopenia.Nke a ebutela ọganihu na usoro nkwadebe platelet.Mgbakwunye na platelet concentrates nwere ike igbochi ọbara ọgbụgba na ndị ọrịa.N'oge ahụ, ndị na-ahụ maka ụlọ ọgwụ na ndị na-ahụ maka ọbara ọbara na ụlọ nyocha nwara ịkwadebe ihe ntinye platelet maka mmịnye.Ụzọ iji nweta ntinye uche etolitela ngwa ngwa ma na-emewanyewanye nke ọma, n'ihi na efere ndị dịpụrụ adịpụ na-efunahụ ngwa ngwa ha, ya mere a ga-echekwa ya na 4 Celsius C ma jiri ya mee ihe n'ime awa 24.

Akụrụngwa na ụzọ

N'afọ ndị 1920, a na-eji citrate mee ihe dị ka ọgwụ mgbochi iji nweta ntinye platelet.Ọganihu na nkwadebe nke platelet gbabara ngwa ngwa na 1950s na 1960 mgbe emepụtara arịa ọbara rọba na-agbanwe agbanwe.Kingsley et al jiri okwu a bụ "plasma bara ụba nke platelet" na mbụ.na 1954 iji zoo aka na ọkwa platelet ọkọlọtọ ejiri maka mmịnye ọbara.Usoro nke ụlọ akụ ọbara mbụ PRP pụtara na 1960 wee bụrụ nke a ma ama na 1970s.N'ọgwụgwụ 1950s na 1960s, a na-eji "EPTA platelet packs" mee ihe.Ntọala ahụ nwere akpa rọba nwere ọbara EDTA nke na-enye ohere ka etinyere platelet site na centrifugation, nke na-akwụsịtụ na obere plasma mgbe a wachara ya ahụ.

Nsonaazụ

A na-eche na ihe ndị na-eto eto (GFs) bụ ihe ndị ọzọ nke PRP na-ezobe na platelet ma na-etinye aka na ya.Ekwenyere echiche a na 1980s.Ọ na-apụta na platelet na-ahapụ ụmụ irighiri ihe ndị na-akpata bioactive (GFs) iji mezie anụ ahụ mebiri emebi, dị ka ọnya akpụkpọ.Ka ọ dị ugbu a, a na-eduzi ọmụmụ ihe ole na ole na-enyocha okwu a.Otu n'ime isiokwu ndị a kacha mụọ na ngalaba a bụ ngwakọta nke PRP na hyaluronic acid.Cohen chọtara ihe na-eto eto na-eto eto (EGF) na 1962. GF ndị sochirinụ bụ ihe na-eto eto na-enweta platelet (PDGF) na 1974 na vascular endothelial growth factor (VEGF) na 1989.

N'ozuzu, ọganihu na nkà mmụta ọgwụ emewokwa ka ọganihu ngwa ngwa na ngwa platelet.Na 1972, Matras bu ụzọ jiri platelet mee ihe dị ka akara iji guzobe homeostasis ọbara n'oge ịwa ahụ.Ọzọkwa, na 1975, Oon na Hobbs bụ ndị ọkà mmụta sayensị mbụ jiri PRP na ọgwụgwọ nrụgharị.Na 1987, Ferrari et al bu ụzọ jiri plasma bara ụba nke platelet dị ka isi mmalite nke mmịnye ọbara na ịwa ahụ obi, si otú a na-ebelata mfu ọbara intraoperative, ọrịa ọbara nke mpụta n'ime akpa ume, na iji ngwaahịa ọbara eme ihe.

Na 1986, Knighton et al.bụ ndị ọkà mmụta sayensị mbụ kọwapụtara ụkpụrụ ịba ụba platelet wee kpọọ ya autologous platelet-derived ọnyá na-agwọ ọrịa (PDWHF).Kemgbe e guzobere ụkpụrụ ahụ, a na-eji usoro a eme ihe na ọgwụ ịchọ mma.A na-eji PRP mee ihe na nkà mmụta ọgwụ na-emegharị ahụ kemgbe njedebe 1980s.

Na mgbakwunye na ịwa ahụ izugbe na ịwa ahụ obi, ịwa ahụ maxillofacial bụ mpaghara ọzọ ebe PRP ghọrọ ewu ewu na mmalite 1990s.A na-eji PRP kwalite njikọ aka na nrụgharị mandibular.A malitekwara itinye PRP na dentistry ma jiri ya kemgbe ngwụcha afọ 1990 iji kwalite njikọ nke eze eze na iji kwalite ọkpụkpụ ọkpụkpụ.Na mgbakwunye, fibrin gluu bụ ihe a maara nke ọma metụtara nke ewepụtara n'oge ahụ.Eji PRP mee ihe na dentistry ka emepụtara site na mmepụta nke platelet-rich fibrin (PRF), ihe nchịkọta platelet nke na-adịghị achọ mgbakwunye ọgwụ mgbochi, site na Choukroun.

PRF bịara na-ewu ewu na mmalite 2000s, yana ọnụ ọgụgụ na-arịwanye elu nke ngwa na usoro eze, gụnyere ịmaliteghachi anụ ahụ hyperplastic gingival na periodontal ntụpọ, mmechi ọnya palatal, ọgwụgwọ nkwụghachi ụgwọ gingival, na aka mmịpụta.

Mkparịta ụka

Anitua na 1999 kọwara iji PRP kwalite ọkpụkpụ n'oge mgbanwe plasma.Mgbe ha hụchara mmetụta bara uru nke ọgwụgwọ ahụ, ndị ọkà mmụta sayensị nyochakwuru ihe omume ahụ.Akwụkwọ ya ndị sochiri ya kọrọ mmetụta ọbara a nwere na ọnya anụ ahụ na-adịghị ala ala, ntinye eze, ọgwụgwọ akwara, na mmerụ ahụ egwuregwu ọkpụkpụ.Ejirila ọtụtụ ọgwụ na-arụ ọrụ PRP, dị ka calcium chloride na bovine thrombin, kemgbe 2000.

N'ihi ihe ndị magburu onwe ya, a na-eji PRP eme ihe na orthopedic.A na-ebipụta nsonaazụ mbụ nke omimi nke mmetụta nke ihe na-eto eto na anụ ahụ anụ ahụ mmadụ na 2005. A na-eji ọgwụgwọ PRP eme ihe ugbu a iji na-agwọ ọrịa ndị na-emebi emebi na ịkwalite ọgwụgwọ nke akwara, ligaments, mọzụlụ na cartilage.Nnyocha na-egosi na usoro a na-aga n'ihu na-ewu ewu na orthopedics nwekwara ike jikọta ya na iji PRP na-emekarị site na kpakpando egwuregwu.N'afọ 2009, e bipụtara nchọpụta anụmanụ na-anwale nke kwadoro echiche ahụ na PRP na-etinye uche na-eme ka ọgwụgwọ anụ ahụ dịkwuo mma.Usoro dị n'okpuru nke ihe PRP na-eme na akpụkpọ ahụ bụ isiokwu nke nchọpụta sayensị siri ike ugbu a.

A na-eji PRP mee ihe nke ọma na dermatology ịchọ mma kemgbe 2010 ma ọ bụ tupu mgbe ahụ.Mgbe ịgbanye PRP, akpụkpọ ahụ dị ka nwata na hydration, mgbanwe na agba na-akawanye mma.A na-ejikwa PRP kwalite uto ntutu.Enwere ụdị PRP abụọ a na-eji ugbu a maka ọgwụgwọ uto ntutu - plasma na-adịghị arụ ọrụ platelet-rich plasma (A-PRP) na plasma-rich platelet (AA-PRP).Agbanyeghị, Gentile et al.gosiri na enwere ike imezi njupụta ntutu na ọnụọgụ ntutu site na ịgbanye A-PRP.Na mgbakwunye, egosila na iji ọgwụgwọ PRP tupu ịkpụgharị ntutu nwere ike ịkwalite uto ntutu na njupụta ntutu.Na mgbakwunye, na 2009, ọmụmụ gosiri na iji ngwakọta nke PRP na abụba nwere ike imezi nnabata abụba na ndụ, nke nwere ike ịkwalite nsonaazụ ịwa ahụ plastik.

Nchọpụta kachasị ọhụrụ sitere na ịchọ mma Dermatology na-egosi na nchikota PRP na CO2 laser therapy nwere ike ibelata ihe otutu nke ukwuu.N'otu aka ahụ, PRP na microneedling mere ka nchịkọta collagen a haziri ahazi na akpụkpọ ahụ karịa PRP naanị.Akụkọ ihe mere eme nke PRP adịghị mkpụmkpụ, na nchoputa metụtara akụkụ ọbara a dị ịrịba ama.Ndị dọkịta na ndị ọkà mmụta sayensị na-achọsi ike maka usoro ọgwụgwọ ọhụrụ.Dịka ụzọ, a na-eji PRP n'ọtụtụ ngalaba ọgwụ, gụnyere gynecology, urology, na ophthalmology.

Akụkọ ihe mere eme nke PRP dịkarịa ala afọ 70.Ya mere, usoro a kwadoro nke ọma ma nwee ike iji ya mee ihe na nkà mmụta ọgwụ.

(A na-ebipụtaghachi ọdịnaya nke isiokwu a, ma anyị anaghị enye nkwa ọ bụla ma ọ bụ nkwenye doro anya maka izi ezi, ntụkwasị obi ma ọ bụ izu oke nke ọdịnaya dị n'ime edemede a, ọ bụghịkwa maka echiche nke isiokwu a, biko ghọta.)